Publications 2010 - 2019
2019
Nent E, Nozaki C, Schmöle AC, Otte D, Zimmer A. (2019). CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain. Sci Rep, 16;9(1):7468. doi: 10.1038/s41598-019-43858-4.
Yeh YN, Hsin KY, Zimmer A, Lin LY, Hung MS. (2019). A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes. Biochem Pharmacol 166:203-211. doi: 10.1016/j.bcp.2019.05.022.
Zanos P, Keyworth H, Georgiou P, Hambsch B, Otte DM, Kitchen I, Zimmer A, Bailey A. (2019). Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia. Eur J Neurosci., doi: 10.1111/ejn.14155.
Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, von Bohlen Und Halbach V, Rath M, Delatycki M, Bert B, Fink H, Blümlein K, Ralser M, Van Dijck A, Kooy F, Stark Z, Müller S, Scherthan H, Gecz J, Wurst W, Wolf E, Zimmer A, Klingenspor M, Graw J, Klopstock T, Busch D, Adamski J, Fuchs H, Gailus-Durner V, de Angelis MH, von Bohlen Und Halbach O, Ropers HH, Kuss AW. (2019). A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene. Biochim Biophys Acta Mol Basis Dis., pii: S0925-4439(18)30497-6. doi: 10.1016/j.bbadis.2018.12.011.
Duerr GD, Heinemann JC, Kley J, Eichhorn L, Frede S, Weisheit C, Wehner S, Bindila L, Lutz B, Zimmer A, Dewald O. (2019). Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. J Mol Cell Cardiol, 133:86-98. doi: 10.1016/j.yjmcc.2019.06.003.
Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E. (2019). Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep., 1;9(1):5457. doi: 10.1038/s41598-019-41991-8.
2018
Schmöle AC, Lundt R, Toporowski G, Hansen JN, Beins E, Halle A, Zimmer A. (2018). Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology. J Alzheimers Dis. 64(2):379-392. doi: 10.3233/JAD-180230.
Nozaki C, Nent E, Bilkei-Gorzo A, Zimmer A. (2018). Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain. Sci Rep, 8(1):10827. doi: 10.1038/s41598-018-28507-6.
Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G. (2018). Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. PLoS One 13(5):e0197751. doi: 10.1371/journal.pone.0197751. eCollection 2018.
Bilkei-Gorzo A, Albayram O, Ativie F, Chasan S, Zimmer T, Bach K, Zimmer A. (2018). Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain. PLoS One. 2018 Aug 16;13(8):e0202566. doi: 10.1371/journal.pone.0202566. eCollection 2018.
Ativie F, Komorowska JA, Beins E, Albayram Ö, Zimmer T, Zimmer A, Tejera D, Heneka M, Bilkei-Gorzo A. (2018). Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity. Front Mol Neurosci., 11:295. doi: 10.3389/fnmol.2018.00295. eCollection 2018.
Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M. (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav., 17(8):e12516. doi: 10.1111/gbb.12516.
Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O. (2018). CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion. Life Sci., 215:96-105. doi: 10.1016/j.lfs.2018.11.003.
Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC. (2018). Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. Proc Natl Acad Sci U S A.,115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.
Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Stöger C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M. (2018) Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic. Behav Brain Res 15;352:187-196. doi: 10.1016/j.bbr.2017.09.048.
Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM. (2018). Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice. Mol Neurobiol., 55(6):4580-4595. doi: 10.1007/s12035-017-0659-3.
2017
Bilkei-Gorzo A, Albayram O, Draffehn AM, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault I, Bab I, Schultze JL & Zimmer A. (2017). A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med, doi: nm.4311.
Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I; German Mouse Clinic Consortium, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, Torres M, Fuchs H, de Angelis MH, Wurst W, Hölter SM, Winkelmann J. (2017). Meis1 effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech., 10(8):981-991.
Ruland C, Renken H, Kuzmanov I, Fattahi Mehr A, Schwarte K, Cerina M, Herrmann A, Otte DM, Zimmer A, Schwab N, Meuth SG, Arolt V, Klotz L, Förster I, Scheu S, Alferink J. (2017). Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease. Brain Behav Immu, 66:382-393.
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D. (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nat Commun. 24;8(1):155.
Schreiner F, Ackermann M, Michalik M, Hucklenbruch-Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J. Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model. (2017). PLoS One, 12(8):e0182754. doi: 10.1371/journal.pone.0182754. eCollection 2017.
2016
Labuz D, Celik MÖ, Zimmer A, Machelska H. (2016). Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. Sci Rep. 6:32799. doi: 10.1038/srep32799.
Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabé de Angelis M. (2016). The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda), 6(12):4035-4046. doi: 10.1534/g3.116.033670.
Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rácz I, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wolf E, Aigner B. (2016). Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PLoS One. 11(3):e0150472. doi: 10.1371/journal.pone.0150472. eCollection 2016.
Stempel AV, Stumpf A, Zhang HY, Özdoğan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Rácz I, Ponomarenko A, Xi ZX, Zimmer A, Schmitz D. (2016). Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. Neuron, 90(4):795-809.
Pósfai B, Cserép C, Hegedüs P, Szabadits E, Otte DM, Zimmer A, Watanabe M, Freund TF, Nyiri G. (2016). Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment. Transl Psychiatry, 6:e807. doi: 10.1038/tp.2016.74.
Celik MÖ, Labuz D, Henning K, Busch-Dienstfertig M, Gaveriaux-Ruff C, Kieffer BL, Zimmer A, Machelska H. (2016). Leukocyte opioid receptors mediate analgesia via Ca2+-regulated release of opioid peptides. Brain Behav Immun. pii: S0889-1591(16)30109-X. doi: 10.1016/j.bbi.2016.04.018. [Epub ahead of print].
Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. (2016). Wiring Specificity and Synaptic Diversity in the Mouse Lateral Central Amygdala. J Neurosci., 36(16):4549-63. doi: 10.1523/JNEUROSCI.3309-15.2016.
Feliszek M, Bindila L, Lutz B, Zimmer A, Bilkei-Gorzo A, Schlicker E. (2016). Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. Naunyn Schmiedebergs Arch Pharmacol. 389(6):603-12.
Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC. (2016). Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. Nat Commun. 7:12199. doi: 10.1038/ncomms12199.
Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiß M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A. (2016). Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism. J Biol Chem, 2016 Jul 29. pii: jbc.M116.746594. [Epub ahead of print].
Beins E, Ulas T, Ternes S, Neumann H, Schultze JL, Zimmer A. (2016). Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia. Glia, 64(6):1007-20.
Beins E, Zimmer A. (2016). Zinc homoeostasis: Basic research indicates therapeutic risks and opportunities. Our Neuropsychopharmacol, 26(6):1083-4.
Zimmer A. (2016). A collaboration investigating endocannabinoid signalling in brain and bone. J Basic Clin Physiol Pharmacy, 27(3):229-35.
Siegmund SV, Wojtalla A, Schlosser M, Schildberg FA, Knolle PA, Nüsing RM, Zimmer A, Strassburg CP, Singer MV. (2016). Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochem Biophys Res Commun, 470(3):678-84.
Zimmer A, Otte DM, Bilkei-Gorzo A, Armin SM, Bab I. (2016). Behavioural changes induced by a conditional disruption of bone formation. J Basic Clin Physiol Pharmacy, 27(3):203-7.
Albayram Ö, Passlick S, Bilkei-Gorzo A, Zimmer A, Steinhäuser C. (2016). Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons. Pflugers Arch, 468(4):727-37.
Jehle J, Hoyer FF, Schöne B, Pfeifer P, Schild K, Jenniches I, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G. (2016). Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice. PLoS One, 2016 Jan 5;11(1):e0146267. doi: 10.1371/journal.pone.0146267.
2015
Royeck M, Kelly T, Opitz T, Otte DM, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H. (2015). Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci. 35(46):15240-53.
Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O. (2015). Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int, 2015:456582. doi: 10.1155/2015/456582. Epub 2015 Oct 11.
Ruhl T, Jonas A, Seidel NI, Prinz N, Albayram O, Bilkei-Gorzo A, von der Emde G. (2015). Oxidation and Cognitive Impairment in the Aging Zebrafish. Gerontology, 62(1):47-57.
Zimmer A. (2015). Genetic Manipulation of the Endocannabinoid System. Handb Exp Pharmacol, 231:129-83.
de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD. (2015). Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet, 47(9):969-78.
Jenniches I, Zimmer A. (2015). Reply To: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence from Two Recent Genetic Endocannabinoid Deficiency Models. Boil Psychiatry, 79(10):e80-1.
Schmöle AC, Lundt R, Gennequin B, Schrage H, Beins E, Krämer A, Zimmer T, Limmer A, Zimmer A, Otte DM. (2015). Expression Analysis of CB2-GFP BAC Transgenic Mice. PLoS One. 2015 Sep 25;10(9):e0138986. doi: 10.1371/journal.pone.0138986. eCollection 2015.
Piyanova A, Lomazzo E, Bindila L, Lerner R, Albayram O, Ruhl T, Lutz B, Zimmer A, Bilkei-Gorzo A. (2015). Age-related changes in the endocannabinoid system in the mouse hippocampus. Mech Ageing Dev, 150:55-64.
Kemter AM, Scheu S, Hüser N, Ruland C, Schumak B, Findeiß M, Cheng Z, Assfalg V, Arolt V, Zimmer A, Alferink J. (2015). The cannabinoid receptor 2 is involved in acute rejection of cardiac allografts. Life Sci, 138:29-34.
Nozaki C, Markert A, Zimmer A. (2015). Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. Eur Neuropsychopharmacol, 25(8):1388-96.
Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P. (2015). MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Dev Cell, 33(6):644-59.
Dewald O, Zimmer A. (2015). Endocannabinoids in adaptation to injury: Ready to move from bench to bedside? Life Sci. 2015 Jun 17. pii: S0024-3205(15)00308-2. doi: 10.1016/j.lfs.2015.06.003. [Epub ahead of print].
Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz B, Bilkei-Gorzo A, Zimmer A. (2015). Anxiety, Stress, and Fear Response in Mice with Reduced Endocannabinoid Levels. Biol Psychiatry, 2015 Apr 14. pii: S0006-3223(15)00314-5. doi: 10.1016/j.biopsych.2015.03.033. [Epub ahead of print].
Pradier B, Erxlebe E, Markert A, Rácz I. (2015). Interaction of cannabinoid receptor 2 and social environment modulates chronic alcohol consumption. Behav Brain Res. 2015 Mar 28;287:163-171. doi: 10.1016/j.bbr.2015.03.051. [Epub ahead of print].
Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A. (2015). Endocannabinoid signaling at the periphery: 50 years after THC. Trends Pharmacol Sci. 2015 Mar 18. pii: S0165-6147(15)00034-6. doi: 10.1016/j.tips.2015.02.008. [Epub ahead of print].
Rácz I, Nent E, Erxlebe E, Zimmer A. (2015). CB1 receptors modulate affective behaviour induced by neuropathic pain. Brain Res Bull, 2015 Apr 8. pii: S0361-9230(15)00059-3. doi: 10.1016/j.brainresbull.2015.03.005. [Epub ahead of print].
Sturm M, Becker A, Schroeder A, Bilkei-Gorzo A, Zimmer A. (2015). Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice. Genes Brain Behav, 14(3):292-300.
Schmöle AC, Lundt R, Ternes S, Albayram O, Ulas T, Schultze JL, Bano D, Nicotera P, Alferink J, Zimmer A. (2015). Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol Aging, 36:710-719.
Di Marzo V, Stella A, Zimmer A. (2015). Endocannabinoid signaling and the deteriorating brain. Nature Rev. Neurosci., 16(1):30-42.
Wasserman E, Tam J, Mechoulam R, Zimmer A, Maor G, Bab I. (2015). CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol. In "MARROW", ed. by M. Zaidi. Ann N Y Acad Sci, 1335(1):110-119.
Ativie F, Albayram O, Bach K, Pradier B, Zimmer A, Bilkei-Gorzo A. (2015). Enhanced microglial activity in FAAH-/- animals. Life Sci, 138:52-56.
2014
Niedermair T, Kuhn V, Doranehgard F, Stange R, Wieskötter B, Beckmann J, Salem P, Springorum HR, Straub RH, Zimmer A, Grifka J, Grässel S. (2014). Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification. Matrix Biol. 38: 22–35.
Heinemann JC, Duerr GD, Keppel K, Breitbach M, Fleischmann BK, Zimmer A, Wehner S, Welz A, Dewald O. (2014). CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes. Life Sci, pii: S0024-3205(14)00948-5. doi: 10.1016/j.lfs.2014.11.027. [Epub ahead of print].
Duerr GD, Heinemann JC, Gestrich C, Heuft T, Klaas T, Keppel K, Roell W, Klein A, Zimmer A, Velten M, Kilic A, Bindila L, Lutz B, Dewald O. (2014). Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life Sci, 2014 Nov 14. pii: S0024-3205(14)00915-1. doi: 10.1016/j.lfs.2014.11.005. [Epub ahead of print].
Mongi-Bragato B, Zamponi E, García-Keller C, Assis MA, Virgolini MB, Mascó DH, Zimmer A, Cancela LM. (2014). Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addict Biol, 2014 Nov 27. doi: 10.1111/adb.12200. [Epub ahead of print].
Thor T, Künkele A, Pajtler KW, Wefers AK, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter SM, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, Hraběde Angelis M, Eggert A, Schramm A, Schulte JH. (2014). MiR-34a deficiency accelerates medulloblastoma formation in vivo. Int J Cancer, 2014 Oct 27. doi: 10.1002/ijc.29294. [Epub ahead of print].
Wood PL, Filiou MD, Otte DM, Zimmer A, Turck CW. (2014). Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse. Schizophr Res, 159(2-3):365-9.
Forstner AJ, Basmanav FB, Mattheisen M, Böhmer AC, Hollegaard MV, Janson E, Strengman E, Priebe L, Degenhardt F, Hoffmann P, Herms S, Maier W, Mössner R, Rujescu D, Ophoff RA, Moebus S, Mortensen PB, Børglum AD, Hougaard DM, Frank J, Witt SH, Rietschel M, Zimmer A, Nöthen MM, Miró X, Cichon S; GROUP Investigators. (2014). Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia. Psychiatry Neurosci, 39(6):386-96.
Otte DM, Raskó T, Wang M, Dreiseidler M, Drews E, Schrage H, Wojtalla A, Höhfeld J, Wanker E, Zimmer A. (2014). Identification of the Mitochondrial MSRB2 as a Binding Partner of LG72. Cell Mol Neurobiol, 34(8):1123-30.
Kemter E, Rathkolb B, Becker L, Bolle I, Busch DH, Dalke C, Elvert R, Favor J, Graw J, Hans W, Ivandic B, Kalaydjiev S, Klopstock T, Rácz I, Rozman J, Schrewe A, Schulz H, Zimmer A, Fuchs H, Gailus-Durner V, de Angelis M, Wolf E, Aigner B. (2014). Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice. J Biomed Sci, 2014 Aug 2;21(1):68. [Epub ahead of print].
Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O. (2014). The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol, 109(4):425.
Melo I, Drews E, Zimmer A, Bilkei-Gorzo A. (2014). Enkephalin knockout male mice are resistant to chronic mild stress. Genes Brain Behav. 13(6):550-8.
Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA. (2014). Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments. PLoS One, 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014.
Friemel CM, Zimmer A, Schneider M. (2014). The CB1 Receptor as an Important Mediator of Hedonic Reward Processing. Neuropsychopharmacology, 39(10):2387-96.
Bilkei-Gorzo A, Mauer D, Michel K, Zimmer A. (2014). Dynorphins regulate the strength of social memory. Neuropharmacology. 77:406-413.
Pradier B, Jeub M, Markert A, Mauer D, Tolksdorf K, Van de Putte T, Seuntjens E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Huylebroeck D, Beck H, Zimmer A, Rácz I. (2014). Smad-interacting protein 1 affects acute and tonic, but not chronic pain. Eur J Pain, 18(2):249-57.
Hambsch B, Keyworth H, Lind J, Otte DM, Racz I, Kitchen I, Bailey A, Zimmer A. (2014). Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia. Br J Pharmacol, doi: 10.1111/bph.12578. [Epub ahead of print].
Kubaczka C, Senner C, Araúzo-Bravo MJ, Sharma N, Kuckenberg P, Becker A, Zimmer A, Brüstle O, Peitz M, Hemberger M, Schorle H. (2014). Derivation and Maintenance of Murine Trophoblast Stem Cells under Defined Conditions. Stem Cell Reports, 30;2(2):232-42.
Szitter I, Pintér E, Perkecz A, Kemény A, Kun J, Kereskai L, Pietra C, Quinn JP, Zimmer A, Berger A, Paige CJ, Helyes Z. (2014). Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant. Inflamm Res, 63:399-409.
Barth A, Bilkei-Gorzo A, Drews E, Otte DM, Diaz-Lacava A, Varadarajulu J, Turck CW, Wienker TF, Zimmer A. (2014). Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity. J Neurochem, 128(6):807-17.
2013
Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G. (2013). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol, 66C:126-132.
Gennequin B, Otte DM, Zimmer A. (2013). CRISPR/Cas-induced double-strand breaks boost the frequency of gene replacements for humanizing the mouse Cnr2 gene. Biochem Biophys Res Commun., 441:815-819.
Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest., 123(8):3272-91.
Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A. (2013). The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol, 24(4):608-20.
Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, Fleischmann BK. (2013). Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 110(46):18710-5.
Montani G, Tonelli S, Sanghez V, Ferrari PF, Palanza P, Zimmer A, Tirindelli R. (2013). Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol., 591:3949-62.
Heidt H, Cinar MU, Uddin MJ, Looft C, Jüngst H, Tesfaye D, Becker A, Zimmer A, Ponsuksili S, Wimmers K, Tholen E, Schellander K, Große-Brinkhaus C. (2013). A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. Mamm Genome, [Epub ahead of print].
Klatte K, Kirschstein T, Otte D, Pothmann L, Müller L, Tokay T, Kober M, Uebachs M, Zimmer A, Beck H. (2013). Impaired d-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J Neurosci, 33(32):13066-80.
Schechter M, Weller A, Pittel Z, Gross M, Zimmer A, Pinhasov A. (2013). Endocannabinoid receptor (CB1R) deficiency affects maternal care and alters the dam's hippocampal oxytocin receptor and BDNF expression. J Neuroendocrinol, doi: 10.1111/jne.12082. [Epub ahead of print].
Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H. (2013). Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice. PLoS One, doi: 10.1371/journal.pone.0071113. eCollection 2013.
Borbély E, Hajna Z, Sándor K, Kereskai L, Tóth I, Pintér E, Nagy P, Szolcsányi J, Quinn J, Zimmer A, Stewart J, Paige C, Berger A, Helyes Z. (2013). Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse. PLoS One, doi: 10.1371/journal.pone.0061684. Print 2013.
Siegmund SV, Wojtalla A, Schlosser M, Zimmer A, Singer MV. (2013). Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochem Biophys Res Commun, 437(1):48-54.
Otte D-M, Barcena de Arellano ML, Bilkei-Gorzo A, Albyram Ö, Imbeault S, Jeung H, Alferink J, Zimmer A. (2013). Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. PLoS ONE, 8(6): e67131, doi:10.1371/journal.pone.0067131.
Duerr GD, Heinemann JC, Dunkel S, Zimmer A, Lutz B, Lerner R, Roell W, Mellert F, Probst C, Esmailzadeh B, Welz A, Dewald O. (2013). Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis. Life Sci, 92(20-21):976-83.
Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, Reglődi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z. (2013). Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides, 43:105-12.
Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. (2013). SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance. PLoS One, 8(6):e66558. doi: 10.1371/journal.pone.0066558.
Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. (2013). A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Neuropharmacology, 71:255-63.
Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Hölter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Garfinkel B, Orly J, Ovcharenko I, Bustin M. (2013). High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner. J Biol Chem, 288(23):16690-703.
Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S. (2013). Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res, 54(5):1360-8.
Becker A, Geisslinger G, Murín R, Grecksch G, Höllt V, Zimmer A, Schröder H. (2013). Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol, 386(5):369-82.
Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, Angelis MH, van der Horst G, Lehmann AR. (2013). SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair, 12:356-366.
Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T. (2013). Cannabinoid 1 Receptors in Keratinocytes Modulate Proinflammatory Chemokine Secretion and Attenuate Contact Allergic Inflammation. J Immunol, 190(10):4929-36.
Rácz I, Markert A, Mauer D, Stoffel-Wagner B, Zimmer A. (2013). Long-term ethanol effects on acute stress responses: modulation by dynorphin. Addict Biol, 18(4):678-88.
Drews E, Otte DM, Zimmer A. (2013). Involvement of the primate specific gene G72 in schizophrenia: From genetic studies to pathomechanisms. Neurosci Biobehav Rev, 37:2410-2417.
2012
Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. (2012). Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet, doi: 10.1371/ journal.pgen.1003071.
Albayram O, Bilkei-Gorzo A, Zimmer A. (2012). Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory. Front Aging Neurosci, 4:34. doi: 10.3389/fnagi.2012.00034.
Berner J, Shvarev Y, Zimmer A, Wickström R. (2012). Hypoxic ventilatory response in Tac1 -/- neonatal mice following exposure to opioids. J Appl Physiol, 14(1):11-22.
Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Höfler H, Höschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stöger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Hrabě de Angelis M. (2012). Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome, 23(9-10):611-22.
Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram O, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. (2012). Studies in humans and mice implicate neurocan in the etiology of mania. Am J Psychiatry,169(9):982-90.
Scheef L, Jankowski J, Daamen M, Weyer G, Klingenberg M, Renner J, Mueckter S, Schürmann B, Musshoff F, Wagner M, Schild HH, Zimmer A, Boecker H. (2012). An fMRI study on the acute effects of exercise on pain processing in trained athletes. Pain, 153(8):1702-14.
Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL 2nd, Zimmer A, Watanabe M, Mackie K, Katona I, Piomelli D, Hohmann AG. (2012). Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia. J Neurosci, 32(28):9457-9468.
Janzer A, Stamm K, Becker A, Zimmer A, Buettner R, Kirfel J. (2012). The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology and the metabolome of fibroblasts. J Biol Chem, 287:30984-30992.
Filiou MD, Teplytska L, Otte DM, Zimmer A, Turck CW. (2012). Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model. J Psychiatr Res, 46(10):1359-65.
Bilkei-Gorzo A, Erk S, Schürmann B, Mauer D, Michel K, Boecker H, Scheef L, Walter H, Zimmer A. (2012). Dynorphins regulate fear memory: from mice to men. J Neurosci, 32(27):9335-43.
Sugawara K, Bíró T, Tsuruta D, Tóth BI, Kromminga A, Zákány N, Zimmer A, Funk W, Gibbs BF, Zimmer A, Paus R. (2012). Endocannabinoids limit excessive mast cell maturation and activation in human skin. J Allergy Clin Immunol, 129(3):726-738.e8.
Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM; Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Cotman SL. (2012). Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS ONE 7 (6), e38310.
John Lin CC, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC. (2012). An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci U S A, 109(2):E76-83.
Schulte K, Steingrüber N, Jergas B, Redmer A, Kurz CM, Buchalla R, Lutz B, Zimmer A, Schlicker E. (2012). Cannabinoid CB(1) receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol, 385(4):385-96.
Wojtalla A, Herweck F, Granzow M, Klein S, Trebicka J, Huss S, Lerner R, Lutz B, Schildberg FA, Knolle PA, Sauerbruch T, Singer MV, Zimmer A, Siegmund SV. (2012). The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells, but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol, 302: G873–G887.
Poppensieker K, Otte DM, Schürmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Förster I, Prinz M, Maier W, Zimmer A, Alferink J. (2012). CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A, 109(10): 3897-3902.
Molica F, Matter CM, Burger F, Pelli G, Lenglet S, Zimmer A, Pacher P, Steffens S. (2012). The cannabinoid receptor CB2 protects against balloon-induced neointima formation. Am J Physiol Heart Circ Physiol, 302:H1064-H1074.
Zádor F, Otvös F, Benyhe S, Zimmer A, Páldy E. (2012). Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors. Neurochem Int. [Epub ahead of print].
Helmut Fuchs, Susanne Neschen, Jan Rozman, Birgit Rathkolb, Sibylle Wagner, Thure Adler, Luciana Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Alexander Bohla, Julia Calzada-Wack, Christian Cohrs, András Frankó, Lillian Garrett, Lisa Glasl, Alexander Götz, Michael Hagn, Wolfgang Hans, Sabine M. Hölter, Marion Horsch, Melanie Kahle, Martin Kistler, Tanja Klein-Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Frauke Neff, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Markus Scheerer, Evelyn Schiller, Felix Schöfer, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Irina Treise, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Jack Favor, Jochen Graw, Hugo Katus, Thomas Klopstock, Markus Ollert, Holger Schulz, Tobias Stöger, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Eckhard Wolf, Martin Klingenspor, Valérie Gailus-Durner, and Martin Hrabě de Angelis. (2012). Chapter 7: Mouse Genetics and Metabolic Mouse Phenotyping. In: K. Suhre (ed.), Genetics Meets Metabolomics: from Experiment to Systems Biology, 85, DOI 10.1007/978-1-4614-1689-0_7, © Springer Science+Business Media, LLC 2012
2011
Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, Pecker F, Mallat A, Lotersztajn S. (2011). Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology, 54(4):1217-26.
Sigel E, Baur R, Rácz I, Marazzi J, Smart T, Zimmer A, Gertsch J. (2011). The major central endocannabinoid directly acts at GABAA receptors. Proc Natl Acad Sci U S A, 108(44):18150-5.
Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, de Angelis MH, Huylebroeck D, Zimmer A, Beck H, Racz I. (2011). The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, 152(10):2384-98.
Dastig S, Nenicu A, Otte DM, Zimmer A, Seitz J, Baumgart-Vogt E, Lüers GH. (2011). Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress. Histochem Cell Biol, 136(4):413-25.
Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lütjohann D, Buchalla R, Zimmer A, Nickenig G. (2011). Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol, 51(6):1007-14.
Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H. (2011). Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. PLoS One, 6(7):e22034.
Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. (2011). Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A, 108(27):11256-61.
Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. (2011). Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int., 31(6):862-72. doi: 10.1111/j.1478-3231.2011.02496.x.
Otte DM, Sommersberg B, Kudin A, Guerrero C, Albayram Ö, Filiou MD, Frisch P, Yilmaz Ö, Drews E, Turck CW, Bilkei-Gorzó A, Kunz WS, Beck H and Zimmer A. (2011). N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 36(11):2233-43.
Braun A, Engel T, Aguilar-Pimentel JA, Zimmer A, Jakob T, Behrendt H, Mempel M. (2011). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. Immunobiology, 15;412(2):134-40.
Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S; Bipolar Disorder Genome Study (BiGS) Consortium, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM. (2011). Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder. Am J Hum Genet., 88(3):372-81.
Specht S*, Frank JK*, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A. (2011). CCL17 controls mast cells for the defense against filarial larval entry. J Immunol., 186(8):4845-52. *equal contribution
Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. (2011). The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis, 17(8):1651-64.
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J. (2011). Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice. J Biol Chem., 286(21):18614-22.
Kuckenberg P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann E, Zimmer A, Brüstle O, Schorle H. (2011) Lineage Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem Cells. Mol Cell Biol., 31(8):1748-56.
Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, StewartJP. (2011). Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P. Neuropeptides, 45: 49-53.
Fuchs H, Durner VG, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Marg W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempe M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, de Angelis MH. (2011). Mouse Phenotyping. Methods: available online.
Kosel M, Bilkei-Gorzo A, Zawatzky R, Zimmer A, Schlaepfer TE. (2011). Pegylated human interferon alpha 2a does not induce depression-associated changes in mice. Psychiatry Res., 185(1-2):243-7.
Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. (2010). CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts. J Bone Miner Res., 26(2):308-316.
2010
Drews E, Racz I, Lacava AD, Barth A, Bilkei-Gorzo A, Wienker TF, Zimmer A. (2010). Quantitative trait loci contributing to physiological and behavioral ethanol responses after acute and chronic treatment. Int. J. Neuropsychopharmacol., 13(2):155-69.
Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. (2010). Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy, 65:698-711.
Murikinati S, Jüttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M. (2010). Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neurophil recruitment. FASEB J., 24(3):788-98.
Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J2, Kunder S, Gailus-Durner V, Fuchs H, Naton B, Schulz H, Beckers J, Busch DH, Burbach JPH, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann U, Graw J. (2010). Microphthalmia, Parkinsonism and Enhanced Nociception in Pitx3416insG Mice. Mamm. Genome, 21(1-2):13-27.
Touriño C, Zimmer A, Valverde O. (2010). THC prevents MDMA-induced neurotoxicity in mice. PLoS ONE, 5(2): e9143.
Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, Kirfel J. (2010). Lysine-Specific Demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis, 31: 512-520.
Patsch C, Peitz M, Otte DM, Kesseler D, Jungverdorben J, Wunderlich FT, Brüstle O, Zimmer A, Edenhofer F. (2010). Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells. Stem Cells, 28(5):894-902.
Frisch P, Bilkei-Gorzó A, Rácz I, Zimmer A. (2010). Modulation of the CRH-system by Substance P / NKA in an animal model of depression. Behav. Brain. Res., 213(1): 103-108.
Agudo J, Martin M, Roca C, Molas M, Bura AS, Zimmer A, Bosch F, Maldonado R. (2010). Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. Diabetologia, 53(12):2629-40.
Becker A, Bilkei-Gorzo A, Michel K, Zimmer A. (2010) Exposure of mice to long-light: a new animal model to study depression. Eur Neuropsychopharmacol, 20(11):802-12.
Cluny NL, Vemuri VK, Chambers AP, Limebeer CL, Bedard H, Wood JT, Lutz B, Zimmer A, Parker LA, Makriyannis A, Sharkey KA. (2010). A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. Br. J. Pharmacol., 161(3):629-42.
Tiyerili V, Zimmer S, Jung S, Wassmann K, Naehle CP, Lütjohann D, Zimmer A, Nickenig G, Wassmann S. (2010). CB(1) receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res Cardiol., 105(4):465-77.
Teixeira-Clerc F, Belot M-P, Manin S, Deveaux V, Zimmer A, Tordjmann T, Mallat A, Lotersztajn S. (2010). Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology, 52(3):1046-59.
Servettaz A, Kavian N, Nicco C, Deveaux V, Chéreau C, Wang A, Zimmer A, Lotersztajn S, Weill B, Batteux F. (2010). Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am J Pathol. 177(1):187-96.
Helyes Z, Elekes K, Sándor K, Szitter I, Kereskai L, Pintér E, Kemény A, Szolcsányi J, McLaughlin L, Vasiliou S, Kipar A, Zimmer A, Hunt SP, Stewart JP, Quinn JP. (2010). Involvement of preprotachykinin A gene-encoded peptides and the neurokinin 1 receptor in endotoxin-induced murine airway inflammation. Neuropeptides, 44 (2010) 399-406.
Bilkei-Gorzo A, Berner J, Zimmermann J, Wickström R, Racz I, Zimmer A. (2010). Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene. Br J Pharmacol., 160(6): 1443-1452.
Bilkei-Gorzo A, Drews E, Albayram O, Piyanova A, Gaffal E, Tueting T, Michel K, Mauer D, Maier W, Zimmer A. (2010). Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1-/- mice. Neurobiol Aging, doi:10.1016/j.neurobiolaging.
Rietschel M, Mattheisen M, Frank J, Treutlein J, Degenhardt F, Breuer R, Steffens M, Mier D, Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Herms S, Wichmann HE, Schreiber S, Jöckel KH, Strohmaier J, Roeske D, Haenisch B, Gross M, Hoefels S, Lucae S, Binder EB, Wienker TF, Schulze TG, Schmäl C, Zimmer A, Juraeva D, Brors B, Bettecken T, Meyer-Lindenberg A, Müller-Myhsok B, Maier W, Nöthen MM, Cichon S. (2010). Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression. Biol. Psychiatry, 68(6):578-85.
Drews E, Zimmer A. (2010). Modulation of alcohol and nicotine responses through the endogenous opioid system. Prog. Neurobiol., 90(1): 1-15.
Braun A, Engel T, Aguilar-Pimentel JA, Zimmer A, Jakob T, Behrendt H, Mempel M. (2010). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. Immunobiology, 412(2):134-40.
Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jäger W, Mann K, Matthäus F, Nöthen M, Rietschel M, Sartorius A, Schütz G, Sommer WH, Sprengel R, Walter H, Wichmann E, Wienker T, Wurst W, Zimmer A. (2010). An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol. 15(4):369-79. doi: 10.1111/j.1369-1600.2010.00276.x.
Beer-Hammer S, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP. (2010). The catalytic PI3K isoforms p110{gamma} and p110{delta} contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol., available online
Onur OA, Kukolja J, Bauer A, Patin A, Otte DM, Jeung H, Jon Shah N, Maier W, Fink GR, Hurlemann R. (2010). The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans, Biol Psychiatry, 67(12):1205-11
Fuchs A, Ringer C, Bilkei-Gorzo A, Weihe E, Roeper J, Schütz B. (2010). Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol., 69(10):1057-70.
Shvarev Y, Berner J, Bilkei-Gorzo A, Lagercrantz H, Wickström R. (2010). Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-). Adv Exp Med Biol., 669:129-32.